Using comparative genomics of schistosome species to better understand the molecular basis of zoonoses

Project overview

Schistosome species are a group of helminths that are a substantial burden to human health across many economically developing regions.

Clinical schistosomiasis occurs in the tropics and subtropics and is caused by four main species, of which Schistosoma japonicum and S. mekongi are traditionally considered zoonotic. Occurring in Africa between S. haematobium and other species, particularly Schistosoma bovis and Schistosoma curassoni, hybridisation may give rise to a further zoonotic schistosome.

Species hybridisation have the potential to increase both the zoonotic potential of the disease and the number of animal reservoirs available to maintain transmission rates to humans. To response effectively to new zoonotic sources of schistosomiasis the basis of speciation and hybridisation are important for schistosome pathogens.

This project will include both substantial bioinformatic training and laboratory-based skills. Expertise gained will include the comparison of genomic resources to identify species specific and species common features. The supervisory team will support the development of the contrasting but complementary skills in both molecular and in silico areas as needed for this project.

The application process

There will be two parts to the application process. This application (Part 1) is for the studentship as part of the OneZoo CDT. If you are chosen for a project, you will then also need to apply for admission (Part 2) to the respective Institution by completing their institutional application process. Details for how to do this will be communicated to successful applicants. 

After the application closing date, a panel will shortlist candidates on the basis of this application form against the following criteria:

• Proven Academic Quality: normally evidenced by an excellent performance at first degree and/or Master’s level, but may also be demonstrated by a record of relevant professional practice;
• Research Potential: evidenced through application responses and supported by performance in research projects at first degree and/or Master’s level, or another form of dedicated preparation for research;
• Personal Motivation and Commitment: evidenced through application responses, by enthusiasm for the subject area, and in relation to career goals.

All applicants will be informed of the shortlisting outcome by no later than mid-March.

Shortlisted applicants can expect contact from their chosen supervisor(s) to discuss your fit for the project in more detail. If you are shortlisted, you will need to attend an interview. Details for this will be communicated to shortlisted applicants.